Work Plan
A brief walk through the project millestones and objetives. This will take place in the next few years.
WP 01
ICARO biochip optimization
and manufacturing
WP1 aim is to develop ICARO chips functionalized with pathogen antigens to be further inter- nalized by immune cells.
1-To identify ICARO-specific chip design requirements (size, material, and shape)
2-To fabricate ICARO chips3-To identify and optimize surface chemistry functionalization for antigen immobilization
A brief walk through the project millestones and objetives. This will take place in the next few years.
WP 02
Characterization of ICARO mechanism of action in vitro
WP2 will characterize the key cellular processes triggered by ICARO biochips in human and murine, professional and non-professional antigen-presenting cells.
1-To define the mechanisms of cellular internalization of ICARO biochips
2-To assess the cytotoxicity of ICARO chips upon internalization
3-To analyse and characterize the immune and metabolic responses elicited by ICARO biochips
A brief walk through the project millestones and objetives. This will take place in the next few years.
WP 03
Characterization of ICARO mechanism of action in vivo
WP3 will characterize the safety and biodistribution of ICARO biochips in mice to ensure their suitability as a vaccine, and to analyse their capacity to elicit protection in animals under patho- gen challenge.
1-To characterize the tolerability and biodistribution of systemic and locally administered ICARO biochips in mice
2-To evaluate the capacity of ICARO biochips to elicit immune responses in mice
3-To analyse the protective capacity of ICARO biochips as a vaccine against a pathogen chal- lenge in mouse models.
A brief walk through the project millestones and objetives. This will take place in the next few years.
WP 04
Regulatory issues and scale-up activitie
The aim of this WP is to foresee and define the next steps to be followed for the further devel- opment of the project outcomes
1-Continued assessment on the applicable technical standards and regulatory guidelines
2-To obtain advice by the EMA on the long-term regulatory pathway for the project results with the future aim of product exploitation.
3-To define a scalable manufacturing plan for ICARO biochips to comply under GMP standards
A brief walk through the project millestones and objetives. This will take place in the next few years.
WP 05
Regulatory issues and scale-up activitie
The aim of this WP is to ensure that the project is responsibly managed, the project results are correctly protected for future exploitation, and the project and its main outcomes are widely disseminated.
1-To define an IP strategy and a technology roadmap
2-To develop an exploitation and business plan for the project exploitable assets
3-To supervise gender issues
Intracellular Carriers Against Resistant microOrganisms
